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目的 探讨正常妊娠与不同程度妊娠高血压综合征 (妊高征 )患者血红细胞内钙含量(IECa2 +)、病理机制、危害和对策。 方法 应用 Fluo- 3/ AM导入红细胞经流式细胞术检测 IECa2 +的方法 ,对 42例不同程度的妊高征患者 IECa2 +进行定量测定 (观察组 ) ,32例正常孕妇为对照组 ,并研究与疾病程度和胎儿宫内窘迫发生的关系。 结果 轻度妊高征患者 IECa2 +含量产前 (10 94±90 ) ,产时 (12 0 4± 88)与正常妊娠产前 (110 2± 89)及产时 (1174± 86 )差异无显著性 (P>0 .0 5 ) ;中、重度妊高征者 (产前 :中度 1195± 72、重度 12 0 6± 96 ;产时 :中度 12 5 6± 81、重度 130 8± 84)较正常妊娠者明显增加。具体表现为 :妊高征患者 IECa2 +含量显著高于正常妊娠 ,且产时较产前显著性增多 (P<0 .0 5 ,P<0 .0 1) ;IECa2 +含量与妊高征患者平均动脉压 (MAP)呈正相关系 (P<0 .0 5 ,P <0 .0 1)。 结论 采取有效的降压措施是使 IECa2 +含量趋于正常水平以减低其危害的主要对策
Objective To investigate the level of intracellular calcium (IECa2 +), pathological mechanism, harms and countermeasures in normal pregnancy and pregnancy induced hypertension syndrome (PIH). Methods The method of detecting erythrocytes by flow cytometry with Fluo-3 / AM was used to detect IECa2 + in 42 PIH patients (observation group) and 32 normal pregnant women as control group With the degree of disease and the relationship between fetal distress. Results There was no significant difference in prenatal (1094 ± 90), preterm (12 ± 4 ± 88) and normal prenatal (110 ± 89) and postnatal (1174 ± 86) (P> 0.05); moderate and severe preeclampsia (prenatal: moderate 1195 ± 72, severe 126 ± 96; moderate: 1256 ± 81, severe 130 8 ± 84 ) Than normal pregnancy significantly increased. Specifically, the content of IECa2 + in patients with PIH was significantly higher than that in normal pregnancy, and the time of labor was significantly higher than that of prenatal (P <0.05, P <0.01). The levels of IECa2 + and PIH Mean arterial pressure (MAP) showed a positive correlation (P <0.05, P <0.01). Conclusion Taking effective antihypertensive measures is to make IECa2 content tend to normal level to reduce the harm of the main countermeasures