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目的分析稳定型心绞痛(SAP)和不稳定型心绞痛(UAP)患者血浆内皮素(ET)和神经肽Y(NPY)的水平与冠心病临床类型及冠状动脉粥样硬化病变程度的关系。方法应用放射免疫法检测52例心绞痛患者和32例经冠状动脉造影证实的正常对照组的血浆ET、NPY水平。结果UAP血浆ET,NPY显著高于SAP和正常对照组(P<0.01),随着冠脉狭窄程度加重,血浆ET、NPY呈现增高趋势。重度狭窄组显著高于轻度和中度狭窄组(P<0.01),3组ET、NPY均高于正常对照组(P<0.01)。结论血浆ET水平与冠脉病变程度呈正相关(r=0.835),NPY水平与冠脉病变程度呈正相关(r=0.809)。
Objective To analyze the relationship between plasma endothelin (ET) and neuropeptide Y (NPY) levels in patients with stable angina pectoris (SAP) and unstable angina pectoris (UAP) and the clinical type of coronary heart disease and the severity of coronary atherosclerosis. Methods Plasma ET and NPY levels were measured by radioimmunoassay in 52 patients with angina pectoris and 32 normal controls confirmed by coronary angiography. Results The plasma ET and NPY in UAP group were significantly higher than those in SAP group and normal control group (P <0.01). With the severity of coronary stenosis, plasma ET and NPY showed an increasing trend. Severe stenosis group was significantly higher than those in mild and moderate stenosis group (P <0.01). ET and NPY in 3 groups were significantly higher than those in control group (P <0.01). Conclusions The level of plasma ET is positively correlated with the degree of coronary artery lesion (r = 0.835). The level of NPY is positively correlated with the degree of coronary artery lesion (r = 0.809).