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目的:探讨结直肠的胃肠道间质瘤(gastrointestinalstromaltumors,GIST)外科治疗效果及其影响因素。方法:对我院1990年1月至2004年3月首次治疗的19例结直肠GIST临床资料和病理切片(含免疫组织化学检查)重新复核并加以随访,分析手术切除的效果以及影响手术疗效的因素。结果:手术者中位生存时间为60.0个月,术后1、3、5年生存率分别为100%、79.3%和69.4%。非扩大切除术者(即肿瘤局部切除和肿瘤及所在器官切除)与扩大切除术者比较,差异有显著性(P=0.001)。完全切除术患者的生存率与肿瘤大小、病理类型、核分裂和复发转移有关;但多因素COX回归分析显示,术后生存率仅与肿瘤大小、核分裂和复发转移相关(P<0.05)。结论:结直肠GIST仍以外科治疗为主,原则上行局部完全切除即可。
Objective: To investigate the surgical treatment of gastrointestinal stromal tumors (GIST) in colorectal cancer and its influencing factors. Methods: The clinical data and pathological sections (including immunohistochemistry) of 19 patients with primary colorectal GIST who were treated for the first time from January 1990 to March 2004 in our hospital were reviewed and followed up to analyze the effect of surgical resection and the effect of surgical treatment factor. Results: The median survival time was 60.0 months. The 1, 3, 5-year survival rates were 100%, 79.3% and 69.4% respectively. There was a significant difference (P = 0.001) between those who underwent extended resection and those who underwent extended resection (ie, tumor resection and removal of tumor and organs). The survival rate of patients undergoing total resection was related to tumor size, pathological type, mitosis and recurrence and metastasis. However, multivariate Cox regression analysis showed that postoperative survival rate was only related to tumor size, mitosis and recurrence and metastasis (P <0.05). Conclusion: Surgical treatment of GIST is still the main colorectal glands, the principle of local partial resection can be.