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目的探讨急性脑梗死(ACI)患者血清肝细胞生长因子(HGF)水平变化的临床意义。方法采用双抗体夹心酶联免疫吸附法定量检测30例脑梗死患者和30例正常对照组的血清HGF水平。结果与正常对照组相比,脑梗死组在病程1、7、14、21d血清HGF浓度均显著增高(P<0.05)。脑梗死组恢复期前各时间点之间差异无统计学意义(P>0.05);不同程度神经功能缺损脑梗死患者在急性期的神经功能缺损程度越重,血清HGF水平越高,差异具有统计学意义(P<0.05)。结论血清HGF水平可作为检测ACI患者病情严重程度的生化指标,对判定病情进展及预后具有一定意义。
Objective To investigate the clinical significance of serum hepatocyte growth factor (HGF) level in patients with acute cerebral infarction (ACI). Methods The levels of serum HGF in 30 patients with cerebral infarction and 30 normal controls were detected by double antibody sandwich enzyme-linked immunosorbent assay. Results Compared with the normal control group, the concentration of serum HGF in the cerebral infarction group was significantly increased at 1, 7, 14 and 21 days (P <0.05). The cerebral infarction group had no significant difference at various time points before recovery (P> 0.05). The severity of neurological deficits in patients with different degrees of neurological deficit cerebral infarction was more severe in the acute phase, the higher the serum HGF level was, the difference was statistically Significance (P <0.05). Conclusion Serum HGF level can be used as a biochemical index to detect the severity of ACI patients, which has certain significance in judging the progression of disease and prognosis.