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目的:探讨宫颈癌患者血清鳞状上皮细胞癌抗原的表达及临床意义。方法:应用ELISA法检测169例宫颈癌患者血清中鳞状上皮细胞癌抗原值。结果:鳞状上皮细胞癌抗原在宫颈癌组中的敏感性为78.7%;治疗后鳞状上皮细胞癌抗原水平较治疗前明显下降,差异有统计学意义(P<0.01),复发和/或转移患者鳞状上皮细胞癌抗原水平较治疗前明显升高(P<0.01);鳞状上皮细胞癌抗原在宫颈癌的表达与临床分期、病理类型、淋巴结转移、浸润肌层深度有关,与病理分级和肿瘤生长方式无相关性。结论:鳞状上皮细胞癌抗原在宫颈癌辅助诊断和疗效判断及预后监测中有重要临床意义。
Objective: To investigate the expression and clinical significance of serum squamous cell carcinoma antigen in patients with cervical cancer. Methods: The antigen value of squamous cell carcinoma in 169 cases of cervical cancer was detected by ELISA. Results: The sensitivity of squamous cell carcinoma antigen was 78.7% in cervical cancer group. The antigen level of squamous cell carcinoma was significantly lower than that before treatment (P <0.01), recurrence and / or The metastasis squamous cell carcinoma antigen level was significantly higher than before treatment (P <0.01); squamous cell carcinoma antigen expression in cervical cancer and clinical stage, pathological type, lymph node metastasis, invasion of myometrial depth, and pathology Grading and tumor growth has no correlation. Conclusion: Squamous cell carcinoma antigen has important clinical significance in the diagnosis and prognosis of cervical cancer.