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目的观察阿魏酸钠治疗妊娠高血压综合征(简称妊高征)蛋白尿的有效性和安全性。方法32例妊高征患者随机分为治疗组和对照组,治疗组12例,每日给予阿魏酸钠200 mg溶于生理盐水250ml中静脉滴注;对照组20例,每日给予川芎嗪80mg溶于5%葡萄糖液250ml中静脉滴注。结果阿魏酸钠治疗组24h尿蛋白下降率明显高于对照组,观察期未出现任何不良反应。结论阿魏酸钠治疗妊高征蛋白尿安全有效。
Objective To observe the efficacy and safety of sodium ferulate in the treatment of proteinuria of pregnancy-induced hypertension (PIH). Methods Thirty-two cases of PIH were randomly divided into treatment group and control group, and 12 cases in treatment group were given 200 mg sodium ferulate per day in 250 ml normal saline intravenously. In control group, 20 cases were given ligustrazine 80mg dissolved in 5% glucose solution 250ml intravenous infusion. Results The decreased rate of urinary protein in the treatment group with sodium ferulate was significantly higher than that in the control group, and no adverse reaction was observed during the observation period. Conclusion Sodium ferulate is safe and effective in treating proteinuria of pregnancy-induced hypertension.