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目的 探讨 3-氧 -乙酰 - 11-脱氧甘草次酸铝 (aluminum 3-oxo -acetyl- 11-deoxogly cyrrhetinate,ADA)对实验性大鼠胃溃疡的保护作用机制。 方法 采用Shay结扎法、醋酸法复制大鼠胃溃疡模型 ,分别测定给药后胃粘液PGE2 含量及胃粘膜血流量 (GMBF) ,并对结果进行统计分析。结果 ADA5 0mg·kg-1,10 0mg·kg-1与对照组相比 ,能显著增加胃内游离粘液和胃壁粘液量及胃壁内PGE2 含量(P <0 .0 1)。连续以ADA灌胃能显著增加胃粘膜血流量 (P <0 .0 1)。结论 ADA的抗溃疡作用与增加胃粘液量 ,促进PGE2 分泌及增加GMBF有关
Objective To investigate the protective effect of aluminum 3-oxo-acetyl-11-deoxoglycyrrhetinate (ADA) on experimental gastric ulcer in rats. Methods The model of gastric ulcer was established by Shay ligation and acetic acid method. The gastric mucosal PGE2 and gastric mucosal blood flow (GMBF) were measured after administration, and the results were statistically analyzed. Results Compared with the control group, ADA5 0 mg · kg-1 and 10 mg · kg-1 significantly increased mucus content in the stomach and gastric mucosa and PGE2 content in the stomach wall (P <0.01). Continuous gastric perfusion with ADA significantly increased gastric mucosal blood flow (P <0.01). Conclusion The anti-ulcer effect of ADA is related to increasing gastric mucus volume, promoting PGE2 secretion and increasing GMBF