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目的 :观察急性心肌梗塞患者于发病 48小时应用洛伐他汀治疗的疗效及对近、中期心血管事件的影响。方法 :对临床确诊为急性心肌梗塞的患者抽血查血脂、血脂总胆固醇 (TC)≥ 4.68mmol L和或低密度脂蛋白 (LDL—C)≥ 2 .60mmol L的患者 ,随机分成服药组和对照组。治疗组 5 0人、对照组 48人分别于服药后 3个月、6个月、12个月抽血查血脂 ,并对临床心血管事件随访登记。结果 :治疗组TC、LDL—C明显下降 ,且治疗组再梗塞率、再住院率、死亡率明显低于对照组。结论 :急性心肌梗塞早期应用洛伐他汀可明显降低TC、LDL—C ,减少再梗塞、再住院率及死亡率
Objective: To observe the curative effect of lovastatin in patients with acute myocardial infarction 48 hours after onset and its effect on the recent and mid-term cardiovascular events. Methods: Patients with clinically diagnosed acute myocardial infarction were randomly divided into medication group and control group. Blood samples were collected for blood lipids, total cholesterol (TC) ≥ 4.68 mmol L and LDL-C ≥ 2.60 mmol L Control group. Fifty-five patients in the treatment group and 48 in the control group were tested for blood lipid levels at 3 months, 6 months and 12 months after taking the drug, and were followed up for clinical cardiovascular events. Results: TC and LDL-C in the treatment group were significantly decreased, and the re-infarction rate, rehospitalization rate and mortality in the treatment group were significantly lower than those in the control group. Conclusion: The early application of lovastatin in acute myocardial infarction can significantly reduce TC, LDL-C, reduce re-infarction, rehospitalization and mortality