心血管疾病是世界范围内的常见病、多发病,细胞移植是治疗心血管疾病的有效途径。而骨髓间质干细胞(BMSC)具有来源广泛、取材方便、免疫源性低、可以分化为心肌细胞、内皮细胞等特点,是治疗心血管疾病的良好种子细胞来源。国内、外学者对BMSC治疗心血管疾病进行了很多的动物实验及部分临床研究,但仍存在很多的问题。本文就BMSC治疗心血管疾病的机制、实验研究、临床研究及所面临的问题作一综述。 Cardiovascular disease is a common disease in the world, frequently-occurring disease, cell transplantation is an effective way to treat cardiovascular disease. Bone marrow mesenchymal stem cells (BMSCs), which have many advantages, such as wide source, easy access, low immunogenicity, differentiation into cardiomyocytes and endothelial cells, are good sources of seed cells in the treatment of cardiovascular diseases. Domestic and foreign scholars conducted a lot of animal experiments and some clinical studies on BMSC in the treatment of cardiovascular diseases, but there are still many problems. This article reviews the mechanisms, experimental studies, clinical studies and problems faced by BMSC in the treatment of cardiovascular diseases.