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目的比较经尿道输尿管镜光动力疗法和钬激光治疗男性尿道内尖锐湿疣的疗效和安全性。方法 126例男性尿道内尖锐湿疣患者随机分为试验组和对照组,每组63例。试验组采用光动力治疗,对照组采用钬激光治疗。治疗后观察疗效、复发率及不良反应。结果试验组患者痊愈率和有效率分别为80.95%(51/63)和95.24%(60/63);对照组患者痊愈率和有效率分别为58.73%(37/63)和82.54%(52/63),两组痊愈率和有效率比较,差异有统计学意义(P<0.01&P<0.05)。所有患者均随访6个月,试验组复发率为12.70%(8/63),明显低于对照组的复发率26.98%(17/63),两组比较差异有统计学意义(P<0.05)。试验组患者治疗后无尿道出血、尿道狭窄和瘢痕,而对照组分别有3例(4.8%)和5例(7.9%)患者出现尿道狭窄和瘢痕。结论经尿道输尿管镜光动力治疗尿道内尖锐湿疣临床有效、不良反应小、复发率低。
Objective To compare the efficacy and safety of transurethral ureteroscopic photodynamic therapy and holmium laser in treatment of male urethral condyloma acuminatum. Methods 126 cases of male urethral condyloma acuminatum were randomly divided into experimental group and control group, 63 cases in each group. The experimental group was treated with photodynamic therapy while the control group was treated with holmium laser. After treatment efficacy, recurrence rate and adverse reactions were observed. Results The cure rate and effective rate in the experimental group were 80.95% (51/63) and 95.24% (60/63), respectively. The cure rate and effective rate in the control group were 58.73% (37/63) and 82.54% (52 / 63). There was significant difference between the two groups in cure rate and effective rate (P <0.01 & P <0.05). All patients were followed up for 6 months. The recurrence rate was 12.70% (8/63) in the experimental group and 26.98% (17/63) in the control group, with significant difference between the two groups (P <0.05) . Patients in the test group had no urethral hemorrhage, urethral stricture, and scarring after treatment, whereas urethral stricture and scarring occurred in 3 (4.8%) and 5 (7.9%) patients in the control group, respectively. Conclusions Transurethral ureteroscopic photodynamic therapy for intravaginal condyloma acuminatum is clinically effective with small adverse reactions and low recurrence rate.