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目的研究小剂量多巴胺治疗新生儿窒息后肾损害的临床疗效。方法选取三门峡市中医院近年收治的窒息合并肾损害的新生儿90例,其中研究组45例给予降颅内压、维持电解质酸碱平衡、吸氧等积极对症治疗,研究组45例在常规组基础上静脉滴注小剂量多巴胺,比较两组患儿治疗前后的血肌酐(Cr)和血尿素氮(BUN)水平。结果两组患儿治疗前血Cr和血BUN比较差异无统计学意义(P>0.05),治疗3 d及治疗7 d后,研究组血BUN水平和血Cr水平均明显低于对照组(P<0.05)。临床疗效上,研究组有效率(62.2%)及总有效率(93.3%)均明显高于对照组(P<0.05),无效率(6.7%)显著低于对照组(17.8%)(P<0.01)。结论小剂量多巴胺治疗新生儿窒息合并肾损害能够显著改善患儿缺血、缺氧状况,促进肾功能恢复,缩短病程,是高效、经济的治疗方法。
Objective To study the clinical efficacy of low-dose dopamine in the treatment of nephropathy after neonatal asphyxia. Methods 90 cases of neonates with asphyxia and renal damage admitted to Sanmenxia Hospital of Traditional Chinese Medicine in recent years were selected. Among them, 45 cases in the study group were given intracranial pressure to maintain the electrolyte acid-base balance, oxygen and other positive symptomatic treatment, 45 cases in the study group Based on the intravenous infusion of small doses of dopamine, compared two groups of children before and after treatment of serum creatinine (Cr) and blood urea nitrogen (BUN) levels. Results There was no significant difference in blood Cr and BUN between the two groups before treatment (P> 0.05). After 3 days of treatment and 7 days of treatment, the level of blood BUN and blood Cr in study group were significantly lower than those in control group (P <0.05). Clinical efficacy, the effective rate (62.2%) and total effective rate (93.3%) of the study group were significantly higher than the control group (P <0.05), the inefficiency (6.7%) was significantly lower than the control group (17.8% 0.01). Conclusion Low dose dopamine treatment of neonatal asphyxia with renal damage can significantly improve the condition of ischemia and hypoxia in children and promote the recovery of renal function and shorten the course of disease. It is an effective and economical treatment.