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目的通过测定妊娠期高血压疾病(简称妊高病)患者新生儿脐血血脂和脂蛋白情况,探讨血脂和脂蛋白异常在其发病中的意义。方法选择2008年12月至2009年12月妊高病患者35例作为妊高病组,正常足月分娩无合并症和并发症孕妇35例作为对照组。采用酶试剂法测定两组新生儿脐血中甘油三酯(TG)、总胆固醇(TC)水平;清除法测定高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)水平;免疫透射比浊法测定载脂蛋白A1、B(apoA1、B)水平,并比较两组脐血中血脂和脂蛋白水平。结果①妊高病组新生儿脐血中TG、TC、LDL-C和apoB水平较对照组明显升高(P<0.05)。②妊高病组新生儿脐血中HDL-C和apoA1水平较对照组降低(P<0.05)。③随着妊高病病情的发展,脐血中TG、TC、LDL-C和apoB水平增高,HDL-C和apoA1水平降低。结论妊高病新生儿脐血中血脂及脂蛋白代谢紊乱,可能与孕妇妊高病的发病有关。
Objective To determine the significance of serum lipoproteins and lipoprotein abnormalities in the pathogenesis of neonatal umbilical blood lipids and lipoproteins in patients with gestational hypertension (PIH). Methods 35 pregnant women with PIH from December 2008 to December 2009 were selected as PIH group. 35 pregnant women without complications and complications during normal term delivery were selected as control group. Serum triglyceride (TG) and total cholesterol (TC) levels were measured by enzyme-linked immunosorbent assay (ELISA). HDL-C and LDL-C levels were measured by clearance assay. The levels of apolipoprotein A1, B (apoA1, B) were determined by immunoturbidimetry and the levels of lipids and lipoproteins were compared between the two groups. Results ① The levels of TG, TC, LDL-C and apoB in cord blood of PIH patients were significantly higher than those in control group (P <0.05). ② The levels of HDL-C and apoA1 in neonatal umbilical blood in PIH group were lower than those in control group (P <0.05). ③ With the development of PIH, the level of TG, TC, LDL-C and apoB in umbilical cord blood increased, and the levels of HDL-C and apoA1 decreased. Conclusions The imbalance of lipid and lipoprotein metabolism in umbilical cord blood of newly diagnosed PIH patients may be related to the incidence of PIH in pregnant women.