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目的了解公立三级医院在职医务人员的高尿酸血症现状,以引起其重视并为其高尿酸血症的防治提供科学依据。方法回顾性查阅某三级医院2015年参加健康体检的在职医务人员的体检资料1 262例,收集其一般情况(年龄、性别)和血尿酸、血清转氨酶、空腹血糖、血压、血脂[甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)]数据,按性别、年龄(≤30岁组,31岁~44岁组,≥45岁组)、高尿酸血症情况分组,进行亚组内比较。采用非条件Logistic回归分析高尿酸血症的相关影响因素。结果本研究中医务人员的尿酸水平和高尿酸血症检出率均较高。≥45岁组的尿酸水平明显高于≤30岁组和31岁~44岁组(P<0.01)。男性的尿酸水平和高尿酸血症检出率均明显高于女性(P<0.01),各年龄组的尿酸水平及高尿酸血症检出率也均明显高于同年龄组的女性(P<0.01)。高尿酸血症组的BMI、收缩压和舒张压、血清谷草转氨酶和谷丙转氨酶、空腹血糖、甘油三酯水平均显著高于血尿酸正常组(P<0.01);高密度脂蛋白水平显著低于尿酸正常组(P<0.01)。非条件logistic回归分析结果显示男性、超重和肥胖、血清转氨酶升高、高血糖、高甘油三酯血症者更容易出现高尿酸血症(OR>1.00且P<0.05)。结论医务人员的高尿酸血症情况堪忧,尤其男性以及中老年者更应当改善不良的生活和饮食习惯,注意高尿酸血症的防治。男性、肥胖和超重、高血糖、高甘油三酯血症、血转氨酶升高可能是高尿酸血症的危险因素,高尿酸血症者需重视代谢综合征和心血管疾病的预防和早期发现。
Objective To understand the current situation of hyperuricemia among serving medical staffs in public tertiary hospitals in order to arouse its attention and provide a scientific basis for their prevention and treatment of hyperuricemia. Methods A retrospective review of 1 262 cases of medical examination of active medical staff in a tertiary health care clinic in 2015 collected general conditions (age and sex) and serum uric acid, serum aminotransferase, fasting blood glucose, blood pressure, blood lipid [triglyceride (TG, HDL-C)] data were grouped according to gender, age (≤30 years old, 31 years old to 44 years old, ≥45 years old group) and hyperuricemia, and subgroups Within comparison. Non-conditional logistic regression analysis of the related factors of hyperuricemia. Results The level of uric acid and hyperuricemia were higher in medical staff in this study. Uric acid levels were significantly higher in ≥45 years old group than ≤30 years old group and 31 years old to44 years old group (P <0.01). The prevalence of uric acid and hyperuricemia were significantly higher in males than in females (P <0.01). The levels of uric acid and hyperuricemia in all age groups were also significantly higher than those in the same age group (P < 0.01). BMI, systolic and diastolic blood pressure, serum aspartate aminotransferase, glutamic-pyruvic transaminase, fasting blood glucose and triglyceride in hyperuricemia group were significantly higher than those in normal uric acid group (P <0.01), and the level of HDL was significantly lower In uric acid normal group (P <0.01). Non-conditional logistic regression analysis showed that male, overweight and obesity, elevated serum transaminases, hyperglycemia, hypertriglyceridemia were more likely to have hyperuricemia (OR> 1.00 and P <0.05). Conclusions Hyperuricemia is a serious problem for medical staff. In particular, men and the elderly should improve their bad living and eating habits and pay attention to the prevention and treatment of hyperuricemia. Men, obesity and overweight, hyperglycemia, hypertriglyceridemia, elevated serum transaminases may be the risk factors for hyperuricemia, hyperuricemia need to pay attention to the prevention and early detection of metabolic syndrome and cardiovascular disease.