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自从δ因子偶然在南意大利发现,并于1977年由意大利学者Rizzetto等首次报告与乙型肝炎病毒(HBV)相关的δ抗原-抗体系统以来,各国学者对其进行了大量研究。本文复习有关文献对δ因子的本质、流行病学及其与感染有关的临床问题综述如下。δ因子的特性及本质δ因子为直径35～37nm的病毒颗粒,在氯化铯中的浮密度为1.25g/cm~8,沉降系数在22nm的HBsAg颗粒和完整HBV(Dane颗粒)之间,分核心和外壳二部分。核心由δ基因和δ抗原组成,外壳为HBsAg。δ基因组是一种独
Since δ-factor was discovered incidentally in southern Italy and was first reported by the Italian scholar Rizzetto et al in 1977, the δ antigen-antibody system associated with Hepatitis B virus (HBV), a large number of studies have been conducted by scholars from various countries. This review of the literature on the nature of δ factor, epidemiology and infection-related clinical issues are summarized below. The delta-factor characteristic and intrinsic delta-factor were virions with 35-37 nm in diameter, with a bulk density of 1.25 g / cm8 in cesium chloride and a sedimentation coefficient between 22 nm HBsAg particles and intact HBV (Dane particles) Sub-core and shell two parts. The core is composed of δ gene and δ antigen, the shell is HBsAg. The delta genome is a unique one