论文部分内容阅读
目的 :考察双氯芬酸钠微乳在家兔体内的药代动力学过程。方法 :家兔单次口服双氯芬酸钠微乳和双氯芬酸钠混悬液后 ,用 HPL C法测定血中双氯芬酸钠浓度。 结果 :双氯芬酸钠微乳和混悬液的 AU C0 -∞ 分别为 13.45 6和 10 .5 84μg· h· m l- 1 ,cmax 1 为 2 .85 2和 3.145 μg/m l,tmax1 为 1.438和 0 .75 0 h。 结论 :双氯芬酸钠微乳在家兔体内吸收过程较为平缓 ,可在较长时间内维持一定的血药浓度。
Objective: To investigate the pharmacokinetics of diclofenac sodium microemulsion in rabbits. Methods: After diclofenac sodium microemulsion and diclofenac sodium suspension were given orally to rabbits, the blood concentration of diclofenac sodium was determined by HPL C method. RESULTS: The AU C0 -∞ of diclofenac sodium microemulsion and suspension were 13.45 6 and 10.584 μg · h · m l-1 respectively, with cmax 1 of 2.852 and 3.145 μg / ml, tmax1 of 1.438 and 0 .75 0 h. Conclusion: Diclofenac sodium microemulsion absorbed slowly in rabbits and can maintain a certain blood concentration for a long time.