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目的:探讨高寒地区自然环境-25℃～-13℃条件下,骨骼肌爆炸伤的病理改变过程,为创-冻伤的救治提供依据。方法:对一组成年实验狗及实验羊,在室外自然寒冷环境-25℃～-13℃中,全身麻醉下用铜制雷管实施爆破伤模型;观察骨骼肌爆炸伤病理组织学改变及超微结构特征。结果:爆炸伤部位的肌组织损伤的病理改变随冷冻的时间延长而呈渐进加重发展,肌细胞超微结构线粒体随时间延长退行性改变而不断的加剧。结论:在爆炸伤基础上再度受冻,机体的各种生理功能受到明显抑制,加重感染的程度,对机体功能造成较大的影响,给治疗带来更大的困难,在高寒区对爆炸伤的早期治疗、防止冻伤具有重要意义。
Objective: To investigate the pathological changes of blast injury of skeletal muscle in the natural environment from -25 ℃ to -13 ℃ in the alpine region, and provide the basis for the treatment of wound-frostbite. Methods: A group of adult experimental dogs and experimental sheep were exposed to natural deer -25 ℃ ~ -13 ℃ under general anesthesia with a copper detonator to observe the changes of histopathology and ultrastructure Structure. Results: The pathological changes of the injured muscle tissue in blast injury gradually progressed with the prolongation of freezing time. The mitochondria ultrastructure of muscle cells degenerated and became more and more degenerative with time. CONCLUSIONS: After the blast injury is re-frozen, the various physiological functions of the body are significantly inhibited, aggravating the degree of infection, which has a greater impact on the function of the body and brings more difficulties to the treatment. In the alpine region, the blast injury Early treatment to prevent frostbite is of great importance.