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目的：探索治疗婴幼儿腹泻的有效给药途径。方法：采用中西医结合的方法，自行研制复方新霉素乳膏外敷脐部治疗婴幼儿细菌性腹泻１１２例，同时进行药代动力学监测，并与口服庆大霉素对照组７８例作比较。结果：治疗组疗效明显优于对照组。第１天和第３天止泻率及平均治愈天数，治疗组分别为２３．２％、８９．３％和２．３０±０．８３天；对照组分别为１．３％、１７．９％和４．４０±１．０４天，经统计学处理两组有显著性差异（Ｐ＜０．０１）。治疗组监测３０例尿液药物浓度，用药后尿液药物浓度均有不同程度的增高，并随时间的延长而增加。结论：本疗法符合中医的内病外治——敷脐疗法和西医药物经皮伤药透皮吸收双重机制，疗效显著，又具有无痛苦、简便易行、安全可靠、患儿易接受等优点。
Objective: To explore effective ways to treat diarrhea in infants and young children. Methods: A total of 112 cases of bacterial diarrhea in infants were treated with compound neomycin cream externally by the method of integrated traditional Chinese and western medicine. Pharmacokinetic monitoring was performed at the same time and 78 cases were compared with the control group of gentamicin . Results: The treatment group was significantly better than the control group. On the first day and the third day, the rate of stopping diarrhea and the average number of days of cure were 23.2%, 89.3% and 2.30 ± 0.83 days in the treatment group and 1.3% and 17.9 in the control group % And 4.40 ± 1.04 days, there was a significant difference between the two groups (P <0.01). The treatment group monitored 30 cases of urinary drug concentration, urinary drug concentrations after treatment increased to varying degrees, and increased with time. Conclusion: The therapy is in line with the internal medicine treatment of external disease - umbilical therapy and transdermal absorption of traditional Chinese medicine, double the mechanism of traumatic injury, significant effect, but also has no pain, easy, safe, reliable, easy to accept children and so on .