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变应性疾病是一类具有遗传易感性的多基因遗传病,受到多个基因的遗传控制。对其发病基因的研究是近年来的热点。本文就已发现的IL-4R上的多个基因多态性位点与变应性疾病的相关联系作一综述,为进一步揭示疾病的遗传学背景和发病机制以及为今后基因诊断和治疗提供线索。
Allergic diseases are a group of polygenic hereditary diseases with genetic predisposition that are genetically controlled by multiple genes. The study of its pathogenesis is a hot spot in recent years. This review summarizes the association between the polymorphic loci of IL-4R and allergic diseases, and provides clues for further revealing the genetic background and pathogenesis of the disease and for future genetic diagnosis and treatment .