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15(R)-15甲基前列腺素E_2(PGE_2)是一种具有显著抗分泌及细胞保护作用的药物.本文报道该药对胃粘膜形态学及细胞动力学方面的影响,探讨其作用机制,并指出这是一种有希望的药物.材料和方法:健康男性25名,随机分成两组:前列腺素组12名,口服PGE_2100μg,qid共2个月,继以安慰剂2个月;安慰剂组13名,给服安慰剂4个月.在研究开始前及试验开始后的第2个月底和第4个月底,分
15(R)-15 methyl prostaglandin E 2 (PGE 2 ) is a drug with significant anti-secretory and cytoprotective effects. This article reported the effect of this drug on gastric mucosal morphology and cell dynamics, and explored its mechanism of action. And pointed out that this is a promising drug. Materials and methods: 25 healthy men were randomly divided into two groups: 12 in the prostaglandin group, oral PGE 2 100 μg, qid for 2 months, followed by placebo for 2 months; placebo In group 13, placebo was given for 4 months. Before the start of the study and at the end of the 2nd and 4th months after the trial began,