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本研究通过建立炎症动物模型，应用三七总皂甙（ＴＳＰＮ）、电针（ＥＡ）进行治疗，并用纳洛酮（Ｎｘ）阻断两者作用，用组织化学的方法对ＴＳＰＮ和ＥＡ的效应进行比较。结果可见痛阈（ＰＴ）在ＴＳＰＮ组、ＥＡ组和ＥＡ加ＴＳＰＮ组均显著提高，且硝基蓝四氮唑试验（ＮＢＴ）阳性的多形核白细胞（ＰＭＮ）和醋酸萘酚酯酶（ＡＮＡＥ）的点型亚群计数均明显增加，以上的全部效应均被纳洛酮部分阻断；ＴＳＰＮ组与Ｎｘ组腹腔肥大细胞脱颗粒率无明显差异。由此可见，ＴＳＰＮ与ＥＡ效应相似，具有明显的抗炎镇痛及免疫调整作用。这提示三七总皂甙可能是阿片样肽受体的激动剂而不具有成瘾副作用。
In this study, animal models of inflammation were established and treated with Panax Notoginseng Saponins (TSPN) and Electroacupuncture (EA), and the effects of both were blocked with naloxone (Nx), and the effects of TSPN and EA were performed with histochemical methods. Compare. The results showed that the pain threshold (PT) was significantly increased in the TSPN group, EA group and EA plus TSPN group, and the nitroblue tetrazolium test (NBT) positive polymorphonuclear leukocytes (PMN) and acetate naphthol esterase (ANAE) The number of spotted subpopulations increased significantly. All of the above effects were partially blocked by naloxone. There was no significant difference in the rate of degranulation of peritoneal mast cells between TSPN group and Nx group. It can be seen that TSPN is similar to the EA effect and has significant anti-inflammatory and analgesic effects as well as immunomodulatory effects. This suggests that Panax notoginseng saponins may be an agonist of opioid peptide receptor without side effects of addiction.