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内皮素是迄今所发现的体内最强的缩血管物质,其与不同亚型的膜受体(包括内皮素受体A(endothelin receptor A,ETA)、B及C)结合后,产生不同甚至相反的病理生理效应。ETB受体主要参与内皮素的清除、血管舒张、水盐平衡,调节细胞增殖或凋亡,似乎作为“保护性受体”发挥作用。在多种心血管疾病发生、发展过程中,由于ETB受体调节异常,这种保护作用被减弱甚至逆转。本文对ETB受体的分布、信号途径、调节方式的研究进展予以综述。
Endothelin is by far the most potent vasoconstrictor substance found in the body, which, when combined with membrane receptors of different subtypes, including endothelin receptor A (ETA), B and C, produces different and even opposite The pathophysiological effects. ETB receptors are mainly involved in the clearance of endothelin, vasodilatation, water and salt balance, and regulation of cell proliferation or apoptosis, and seem to play a role as “protective receptors ”. In a variety of cardiovascular diseases, the development process, due to abnormal ETB receptor regulation, this protective effect is weakened or even reversed. This article reviews the distribution of ETB receptors, the signaling pathways, regulatory approaches.