论文部分内容阅读
目的:观察紫杉醇、顺铂、亚叶酸钙及5-氟尿嘧啶联合治疗胃癌的临床疗效及副反应。方法:纳入晚期胃癌患者34例为观察对象,随机分为观察组和对照组各17例,观察组给予紫杉醇(TAx)140mg/m2加入5%葡萄糖注射液或0.9%氯化钠注射液500ml静滴3h,第1、7天各1次;CDDP40mg/m2,静脉滴注并水化,第2～4天;亚叶酸钙(CF)200mg/m2静滴2h,氟尿嘧啶(5-FU)300mg/m2静脉推注后,第2天再1000mg/m2静滴42h。然后停药,21d为1周期,重复给药,3个疗程后观察疗效。对照组除紫杉醇外,其他给药如观察组,周期、疗程同观察组。观察组于治疗前给予抗超敏反应预处理。结果:观察组总有效9例(58.8%)。对照组总有效6例(41.2%)。两组比较差异有显著性意义(P<0.05)。两组不良反应主要包括骨髓抑制、消化道反应、肝脏毒性,无超敏反应,无肾功能损害。两组不良反应差异无显著性意义(P>0.05)。结论:紫杉醇、顺铂、亚叶酸钙及5-氟尿嘧啶联合治疗胃癌是一种非常有效的方法。
Objective: To observe the clinical efficacy and side effects of paclitaxel, cisplatin, leucovorin and 5-fluorouracil in the treatment of gastric cancer. Methods: Thirty-four patients with advanced gastric cancer were randomly divided into observation group (17 cases) and control group (17 cases). Patients in observation group were treated with paclitaxel (TAx) 140mg / m2 with 5% glucose injection or 0.9% sodium chloride injection 500ml Dripped for 3h and once daily for 1 and 7 days; CDDP 40mg / m2, intravenous drip and hydration for 2-4 days; 200mg / m2 calcium folinate infusion for 2h, 5-fluorouracil 300mg / m2 intravenous injection, the first 2 days and then intravenous infusion of 1000mg / m2 42h. Then stop drug, 21d for 1 cycle, repeated administration, 3 after treatment to observe the effect. In addition to paclitaxel in the control group, other administration such as observation group, cycle, treatment with the observation group. The observation group was given anti-hypersensitivity pretreatment before treatment. Results: The observation group, the total effective in 9 cases (58.8%). Control group, the total effective in 6 cases (41.2%). There was significant difference between the two groups (P <0.05). Two groups of adverse reactions include bone marrow suppression, gastrointestinal reactions, liver toxicity, no hypersensitivity, no renal damage. No significant difference between the two groups of adverse reactions (P> 0.05). Conclusion: Paclitaxel, cisplatin, leucovorin and 5 - fluorouracil combined treatment of gastric cancer is a very effective method.