目的 :评价利多卡因和沙丁胺醇联合雾化吸入治疗中、重度哮喘的疗效和安全性。方法 :选择符合中、重度哮喘诊断的成年入院病例 6 0例 ,随机分为治疗组和对照组各 32例。治疗组联合应用利多卡因和沙丁胺醇超声雾化吸入治疗哮喘 ,对照组单纯应用沙丁胺醇超声雾化吸入。测定入院当天、治疗 2周后的FEV1、PEFR值。结果 :治疗组和对照组临床控制率分别为 75 .0 %和 5 0 .0 % (P <0 .0 5 ) ;治疗 2周后治疗组肺功能有明显改善。结论 :联合应用利多卡因和沙丁胺醇超声雾化吸入治疗中、重度哮喘较单纯应用沙丁胺醇效果良好 ,改善肺功能显著 Objective: To evaluate the efficacy and safety of lidocaine combined with salbutamol inhalation in the treatment of moderate and severe asthma. Methods: Sixty adult patients admitted to hospital for moderate and severe asthma were randomly divided into treatment group (32 cases) and control group (32 cases). The treatment group was treated with lidocaine and salbutamol inhalation combined with inhalation for the treatment of asthma, while the control group was treated with salbutamol alone. On the day of admission, the FEV1 and PEFR values ​​after 2 weeks of treatment were measured. Results: The clinical control rates of the treatment group and the control group were 75.0% and 50.0% (P <0.05), respectively. After 2 weeks of treatment, the lung function of the treatment group was significantly improved. CONCLUSIONS: Combined use of lidocaine and salbutamol inhalation for the treatment of moderate and severe asthma is better than salbutamol alone, improving pulmonary function