目的探讨米索前列醇用于足月引产的最佳剂量,以减少副作用,提高阴道分娩的成功率。方法选择有引产指征,无禁忌症的初产妇500例,年龄20~35岁,妊娠37~42 W。随机分为A组(米索25μg q3 h)和B组(米索50μg q3 h)各250例。两组均为阴道后宫隆置药。结果两组均有促宫颈成熟作用,且效果明显,A组总有效率93.2%,B组总有效率95.2%,两组之间差异无统计学意义(P>0.05),但A组宫缩过强及羊水Ⅲ度污染的发生率均低于B组,差异有统计学意义(P<0.01,P<0.01)。结论25μg和50μg米索前列醇应用晚期妊娠引产同样有效,但A组母婴更安全。 Objective To investigate the optimal dose of misoprostol for term induction of labor to reduce side effects and improve the success rate of vaginal delivery. Methods: There were 500 primiparae women with indications of induction of labor and no contraindications, aged from 20 to 35 years old and 37 to 42 weeks of gestation. Randomly divided into group A (25μg qs h of misoprostol) and group B (250μg qs h of misoprostol) 250 cases. Both groups were vaginal posterior uterus Lung medicine. Results Both groups had cervical ripening effect, and the effect was obvious. The total effective rate in group A was 93.2% and that in group B was 95.2%. There was no significant difference between the two groups (P> 0.05) Too strong and amniotic fluid Ⅲ degree of contamination were lower than the incidence of B group, the difference was statistically significant (P <0.01, P <0.01). Conclusions 25μg and 50μg misoprostol are equally effective in inducing late pregnancy, but the mothers in group A are safer.