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人体感染病原体时激发的天然免疫反应一直是研究的热点。浆细胞样树突状细胞(Plasmacytoid dendrtic cell,pDC)是病毒感染时激发人体免疫反应的重要细胞。它能在Toll样受体(TLR)的辅助下识别病原体并分泌大量I型IFN及趋化因子等细胞因子,本文综述了单纯疱疹病毒感染人体时pDC及TLR在机体免疫反应中的作用。
The natural immune response stimulated by the human body when infected with pathogens has been a hot spot of research. Plasmacytoid dendrtic cell (pDC) is an important cell that stimulates the human immune response when the virus is infected. It can identify pathogens with the help of Toll-like receptors (TLRs) and secrete a large number of cytokines such as type I IFNs and chemokines. This review summarizes the role of pDC and TLR in the immune response of the human body when the herpes simplex virus is infected.