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利福霉素类致急性肾衰并非罕见,本文分析报告3例,结合文献提出早期诊断的重要性。老年、糖尿病、间歇用药与间断后再用药的病人,尤须注意。急性肾损害最先出现尿改变,在用药前与用药中应多次作尿常规与肾功能检查。正确的治疗方法是停药,采用肾衰综合治疗,重症可用床旁血液透析与激素治疗,预后良好。肾功恢复后不宜再次用利福霉素类药物,也不宜用激惹试验来证实诊断。
Rifamycin-induced acute renal failure is not uncommon, this report analysis of 3 cases, combined with the literature put forward the importance of early diagnosis. Elderly, diabetes, intermittent medication and intermittent use of drugs, especially the attention. Acute renal damage first appeared in urine changes, medication and medication should be repeated for urinalysis and renal function tests. The correct treatment is withdrawal, the comprehensive treatment of renal failure, severe bedside hemodialysis and hormone therapy available, the prognosis is good. Kidney recovery should not be used again after rifamycins, but also not to use irritation test to confirm the diagnosis.