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以磺化碱木质素聚氧乙烯醚(SAL-PEG)/聚乙烯亚胺(PEI)为壁材,阿维菌素原药为芯材,采用静电自组装法制备了木质素基阿维菌素微胶囊(AVM-CS)。考察了芯壁比(芯材与壁材的质量比)、交联剂用量、交联反应pH、NaCl溶液浓度对微胶囊成囊性能和缓释性能的影响,得到最优AVM-CS成囊条件为:芯壁比为2∶5、戊二醛用量为4%(戊二醛质量占壁材质量的百分比,下同)、壁材发生交联时的反应液pH=8,在1 mol/L NaCl溶液中成囊。制备的AVM-CS呈不规则球状,粒径范围1~5μm。缓释性能测定结果发现,以AVM-CS与聚氨酯为壁材制备的阿维菌素微胶囊(PU-CS)的缓释效果相当,AVM-CS的原药累积释药量大于93%,高于87%的PU-CS的原药释药量。
In this study, SAL-PEG / PEI as the wall material and abamectin as the core material were prepared by electrostatic self-assembly method. Micro-capsules (AVM-CS). The effects of core-wall ratio (the mass ratio of core to wall), the amount of cross-linking agent, the pH of the cross-linking reaction and the concentration of NaCl solution on the encapsulation performance and sustained release performance of the microcapsules were investigated. The conditions are as follows: the ratio of core to wall is 2: 5, the amount of glutaraldehyde is 4% (the mass of glutaraldehyde accounts for the mass of wall material, the same below) / L NaCl solution into capsules. AVM-CS prepared was irregular spherical, particle size range 1 ~ 5μm. The results of sustained-release test showed that the sustained-release effect of AVM-CS and PU-CS was equal to that of AVM-CS. The cumulative release of AVM-CS was more than 93% In 87% of PU-CS’s original drug release.