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随着中西医结合的发展 ,中西药联用在临床上也越来越普遍 ,合理的中西药联用能发挥中西药的协同作用 ,而不合理的中西药联用不仅会产生或增加不良反应外 ,还会导致拮抗作用。从药动学 (吸收、分布、代谢、排泄 )、药效学、理化反应等方面对中西药联用的拮抗作用及其机理作了探讨。其中吸收上的拮抗作用包括联用产生的胃肠道酸碱度变化、胃肠蠕动改变、络合物、螯合物和沉淀物形成及吸附作用。中西药联用拮抗作用的机理尚未完全明了 ,它需要通过长期临床经验的积累和实验室的研究来逐步地归纳、总结。
With the development of integrated traditional Chinese and Western medicine, the combination of traditional Chinese and western medicine is also becoming more and more common in clinic. Rational combination of traditional Chinese and western medicine can exert the synergistic effect of traditional Chinese and western medicine. However, unreasonable combination of traditional Chinese and western medicine not only produces or increases adverse reactions In addition, it can also cause antagonism. The antagonism and its mechanism of combination of Chinese and Western medicine were discussed from the aspects of pharmacokinetics (absorption, distribution, metabolism, excretion), pharmacodynamics, physicochemical reaction and so on. Among the antagonistic effects on absorption include gastrointestinal pH changes, changes in gastrointestinal motility, complexes, chelates and sediment formation and adsorption. The mechanism of Chinese and Western medicine combined antagonism is not yet fully understood, which needs to be gradually summarized and summarized through the accumulation of long-term clinical experience and laboratory studies.