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目的探讨鼻腔原发性透明细胞癌的临床病理特点和鉴别诊断要点。方法结合文献对1例鼻腔透明细胞癌的临床资料、病理特征、免疫表型及治疗预后进行分析。结果典型的组织学特征表现为多边形上皮样瘤细胞组成,排列成巢状,由富含薄壁毛细血管的纤维组织分隔。瘤细胞大小不一,胞质丰富透亮,呈空泡状,核小,核分裂罕见。免疫组化:肿瘤细胞显示EMA(+)、CKpan(+)、CD10(-)、CK7(-)、HMB45(-)、S-100(-)、Calponin(-)、SMA(-)、GFAP(-)、TG(-)。结论鼻腔原发透明细胞癌是罕见的肿瘤,其诊断和鉴别诊断主要依靠病理组织学、免疫组织化学。
Objective To investigate the clinicopathological features and differential diagnosis of primary clear cell carcinoma of nasal cavity. Methods The clinical data, pathological features, immunophenotypes and prognosis of 1 case of clear cell carcinoma of nasal cavity were analyzed in combination with the literature. Results The typical histological features of polygonal epithelioid tumor cells, arranged in nests, separated by thin-walled capillary-rich fibrous tissue. Tumor cells of different sizes, rich and transparent cytoplasm, vacuolar, small nucleus, rare mitotic. Immunohistochemistry: The tumor cells showed positive expression of EMA, CKpan, CD10, CK7, HMB45, S-100, Calponin, SMA, (-), TG (-). Conclusions Primary nasal clear cell carcinoma is a rare tumor whose diagnosis and differential diagnosis depend mainly on histopathology and immunohistochemistry.