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目的探讨中国Brugada综合征的发病现状、临床特征和诊治情况。方法选择1998年1月至2013年6月在CNKI、万方数据库、维普数据库、Pubmed中以“Brugada”为自由词或关键词,检索国人发表的Brugada病例182例。采用回顾性方法,对资料进行汇总分析。结果 Brugada综合征患者男女之比14.7∶1,中位年龄41岁;25例有家族猝死史,5例有家族Ⅰ型Brugada波。72.3%有晕厥史,晕厥年龄(43.0±12.0)岁。39.0%记录到多形性室性心动过速/心室扑动/心室颤动。71例行心电生理检查,阳性率49.3%。药物激发试验阳性率为92.9%。10例误诊。埋藏式心脏转复除颤器(ICD)植入占指南推荐的19.8%。猝死率8.2%,猝死年龄(48.7±16.7)岁。结论近15年来中国报道182例Brugada综合征,其特点:累及年龄广,中青年为主,男性居多,晕厥为其最主要的临床表现,药物激发试验及心电生理检查阳性率高,治疗现状不规范,ICD植入率低,猝死率高。
Objective To investigate the incidence, clinical features and diagnosis and treatment of Brugada syndrome in China. Methods From January 1998 to June 2013, 182 cases of Brugada cases were searched from CNKI, Wanfang database, VIP database and Pubmed using “Brugada” as a free word or key word. Using a retrospective approach, a summary of the data analysis. Results The ratio of men to women in Brugada syndrome was 14.7:1, with a median age of 41 years. There were 25 cases with sudden family history of death and 5 cases with family type Ⅰ Brugada waves. 72.3% had a history of syncope, and the syncope age (43.0 ± 12.0) years. 39.0% recorded pleomorphic ventricular tachycardia / ventricular flutter / ventricular fibrillation. 71 routine electrophysiological examination, the positive rate of 49.3%. The positive rate of drug challenge test was 92.9%. 10 cases misdiagnosed. Buried cardiac defibrillator (ICD) implantation accounted for 19.8% of the recommended guidelines. Sudden death rate of 8.2%, sudden death (48.7 ± 16.7) years of age. Conclusions 182 cases of Brugada syndrome have been reported in China in the past 15 years. The characteristics of this syndrome are as follows: the age, middle-aged and young people are predominant, the majority are male, and syncope is the most important clinical manifestation. The positive rate of drug provocation test and electrophysiological examination is high. Non-standard, ICD implantation rate is low, the high rate of sudden death.