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目的分析成都市严重疑似预防接种异常反应(Serious adverse event following immunization,SAEFI)发生特征,探讨疫苗安全性及监测质量。方法通过中国免疫规划信息管理系统疑似预防接种异常反应(Adverse event following immunization,AEFI)监测模块,收集2013-2015年成都市报告的SAEFI病例,进行描述性流行病学分析。结果2013-2015年成都市报告AEFI共6 379例,报告发生率为43.53/10万剂,其中SAEFI 57例,报告发生率0.38/10万剂,男性报告数多于女性,年龄多在2岁内,共涉及18种疫苗,72.97%在接种第1剂次疫苗后发生,5例死亡病例经诊断后均为偶合症,其余SAEFI预后良好。结论成都市AEFI监测敏感性较高,SAEFI发生率远低于预期,疫苗安全性和预防接种服务良好。
Objective To analyze the characteristics of Serious adverse event following immunization (SAEFI) in Chengdu and discuss the safety and quality of vaccines. Methods Adverse event following immunization (AEFI) monitoring module was used in China immunization program information management system to collect the reported cases of SAEFI in Chengdu in 2013-2015 for descriptive epidemiological analysis. Results A total of 6 379 AEFI cases were reported in Chengdu in 2013-2015, with a reported incidence rate of 43.53 / 100 000, of which 57 were SAEFI with a reported incidence of 0.38 / 100 000, more men than women and more than 2 years of age In total, 18 vaccines were involved, 72.97% occurred after the first dose of vaccination, and 5 death cases were diagnosed as having complications. The remaining SAEFI had a good prognosis. Conclusion The sensitivity of AEFI surveillance in Chengdu is high, the incidence of SAEFI is much lower than expected, and the vaccine safety and vaccination services are good.