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血红蛋白是血液循环中输送氧的载体。糖尿病病人的血液中糖基化血红蛋白含量增加 ,影响了输氧的能力。我们用EXAFS法测定了正常人、轻度糖尿病病人以及重度糖尿病病人血红蛋白中铁原子的近邻结构。观察了糖尿病与血红蛋白结构的关系。结果表明 ,3种样品中铁原子的配位数和Fe—O键长基本相同 ,但重度糖尿病病人样品的Fe—N键长增加了 0 .0 0 2nm。这可能是由于他们的血液中脱氧血红蛋白的含量增加所引起
Hemoglobin is the carrier of oxygen in the blood circulation. Glycosylated hemoglobin levels increase in the blood of diabetic patients, affecting the ability to deliver oxygen. We used EXAFS method to determine the neighboring structure of iron atoms in hemoglobin of normal people, mild diabetic patients and severe diabetic patients. Observe the relationship between diabetes and hemoglobin structure. The results showed that the coordination numbers of iron atoms and Fe-O bond lengths in the three samples were basically the same, but the Fe-N bond length of the samples of patients with severe diabetes increased by 0.002 nm. This may be due to the increased levels of deoxy-hemoglobin in their blood