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运用漂浮导管热稀释法监测汉防己素（简称汉甲）对１０名健康受试者及１２例高血压病患者的急性血液动力学作用。结果：对正常人，汉甲减慢心率（ＨＲ），升高平均肺动脉压（ＭＰＡＰ）和肺毛细血管嵌顿压（ＰＣＷＰ），而平均动脉压（ＭＡＰ）、心输出量（ＣＯ）、心脏指数（ＣＩ）用药前后差异无显著性。对高血压病患者，汉甲明显降低ＭＡＰ、ＭＰＡＰ、ＰＣＷＰ，明显升高ＣＯ、ＣＩ，对ＨＲ无影响。提示汉甲具有潜在负性变力性与负性变时性效应，对正常血压无影响；但对高血压病患者，汉甲在安全有效降压的同时，能促进左室功能的改善。
The use of floating catheter thermodilution method for monitoring tetrandrine (Han) for 10 healthy subjects and 12 cases of hypertensive patients with acute hemodynamic effects. Results: In normal subjects, NHA slows heart rate (HR), increases mean pulmonary artery pressure (MPAP) and pulmonary capillary pressure (PCWP) while mean arterial pressure (MAP), cardiac output Index (CI) medication before and after the difference was not significant. Hypertension patients, Han significantly lower MAP, MPAP, PCWP, significantly increased CO, CI, no effect on HR. Suggesting that Nail has latent negative variability and negative chronotropic effects, no effect on normal blood pressure; but in patients with hypertension, Nail safe and effective antihypertensive at the same time, can promote the improvement of left ventricular function.