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目的探讨卵巢未成熟畸胎瘤继发腹膜黑变病的临床病理特征。方法对1例腹膜黑变病临床、组织病理学、特殊染色、免疫组化结果进行分析,并复习文献。结果患者女性,30岁。因“胆囊炎、胆石症”腹腔镜下行胆囊切除术。巨检发现胆囊浆膜面黑色斑块。镜下见大量含黑色素细胞,排列成巢状及腺泡状,脱色素后,细胞清晰,胞质透明,核圆形及卵圆形。免疫组化示部分细胞CD68(+),部分细胞NSE、GFAP和S-100(+)。未经任何治疗,随访16个月,无任何症状。结论患者因卵巢未成熟畸胎瘤破裂继发腹膜黑变病。
Objective To investigate the clinicopathological features of secondary peritoneal melanosis in immature ovarian teratoma. Methods One case of peritoneal melanosis clinical, histopathology, special staining, immunohistochemistry results were analyzed, and reviewed the literature. Results Female patient, 30 years old. Because of “cholecystitis, cholelithiasis” laparoscopic cholecystectomy. Giant semen found gallbladder serosa black plaque. Microscopic see a large number of melanoma cells, arranged in nests and acini, depigmentation, the cells clear, transparent cytoplasm, nuclear round and oval. Immunohistochemistry showed that some cells were CD68 (+), some cells were NSE, GFAP and S-100 (+). Without any treatment, follow-up 16 months without any symptoms. Conclusion Patients with secondary rupture of ovarian immature teratoma peritoneal melanosis.