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目的:研究基质金属蛋白酶-2(MMP-2)与脑血管畸形的关系。方法:选择脑血管畸形患者50例作为观察组,同时选择50例体检中心的正常人作为对照组,取两组患者的血液,对比MMP-2水平。结果:观察组血清MMP-2水平在发病第1天、第7天和第14天均明显高于对照组(P<0.05),而且观察组血清MMP-2水平在第7天明显高于第1天和第14天(P<0.05)。结论:MMP-2的表达异常与脑血管畸形呈正相关关系。
Objective: To investigate the relationship between matrix metalloproteinase-2 (MMP-2) and cerebrovascular malformations. Methods: Fifty patients with cerebrovascular malformations were selected as the observation group and 50 normal subjects in the physical examination center were selected as the control group. The blood levels of the two groups of patients were compared with that of MMP-2. Results: The levels of serum MMP-2 in the observation group were significantly higher than those in the control group on the 1st, 7th and 14th days (P <0.05), and the serum MMP-2 level in the observation group was significantly higher than that on the 7th day 1 day and 14 days (P <0.05). Conclusion: The abnormal expression of MMP-2 has a positive correlation with cerebrovascular malformations.