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目的观察胺碘酮与伊布利特对老年转复消融术后持续性心房颤动的临床疗效。方法 104例持续性老年心房颤动患者,按照随机数字表法分为试验组及对照组,各52例。试验组给予胺碘酮150 mg,生理盐水稀释至20 m L后,30min内静脉推注完毕。对照组给予伊布利特1 mg,生理盐水稀释至20 m L后,10min内静脉推注完毕。比较2组患者心房颤动转复情况,并观察其不良反应发生情况。结果对照组临床总有效率为92.3%,显著高于试验组的59.6%(P<0.05),其转复时间显著低于试验组,且QTc延长幅度低于试验组(P<0.05)。对照组和试验组不良反应发生率分别为17.3%,13.5%,差异无统计学意义(P>0.05)。结论伊布利特可有效保证老年心房颤动患者射频消融术后早期转复,具有较快的起效时间及良好的安全性。
Objective To observe the clinical effects of amiodarone and ibutilide on persistent atrial fibrillation after eluting ablation. Methods A total of 104 patients with persistent senile atrial fibrillation were divided into experimental group and control group according to the random number table method, with 52 cases in each group. The experimental group was given amiodarone 150 mg, saline diluted to 20 m L, 30min intravenous injection is completed. Control group was given ibutilide 1 mg, saline diluted to 20 m L, 10min intravenous injection is completed. Atrial fibrillation in two groups were compared, and the incidence of adverse reactions was observed. Results The total effective rate of the control group was 92.3%, which was significantly higher than that of the experimental group (59.6%, P <0.05). The recovery time of the control group was significantly lower than that of the experimental group and the QTc prolongation was lower than that of the experimental group (P <0.05). The incidence of adverse reactions in the control and experimental groups were 17.3% and 13.5%, respectively, with no significant difference (P> 0.05). Conclusion Ibutilide can effectively ensure the elderly patients with atrial fibrillation in the early post-radiofrequency ablation, with faster onset time and good safety.