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目的：探讨艾司西酞普兰联合认知疗法治疗广泛性焦虑障碍的临床疗效和安全性。方法将60例广泛性焦虑障碍患者随机分为两组，每组30例，均口服艾司西酞普兰治疗，研究组在此基础上联合认知疗法治疗，观察8周。于治疗前后采用汉密顿焦虑量表、临床疗效总评量表中疗效总评量表评定临床疗效。结果治疗2周末起两组汉密顿焦虑量表、临床疗效总评量表中疗效总评量表评分均较治疗前显著降低（P＜0．01），研究组显著低于对照组（P＜0．01）。两组不良反应发生率比较差异无显著性（P＞0．05）。结论艾司西酞普兰联合认知疗法治疗广泛性焦虑障碍疗效显著，优于单用艾司西酞普兰治疗。“,”Objective To explore the efficacy and safety of escitalopram plus cognitive therapy (CT ) for generalized anxiety disorder (GAD) .Methods Sixty GAD patients were randomly divided into two groups of 30 ones each ,both groups took orally escitalopram ,and on this basis research group was plus CT for 8 weeks .Efficacies were assessed with the Hamilton Anxiety Scale (HAMA) ,Clinical Global Impression‐Global Improvement (CGI‐GI) before and after treatment .Results Since the end of the 2nd week the HA‐MA and CGI‐GI scores of both groups lowered more significantly compared with pretreatment (P<0 .01) , so did those in research than control group (P0 .05) .Conclusion Escitalopram plus CT has an evident effect compared with single escitalopram in GAD .