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目的 观察肠道缺血再灌注 (IIR)损伤对肺磷脂的影响。方法 制作IIR大鼠模型 ;肺磷脂组份采用毛细管电泳法分析。结果 肠道缺血 6 0min再灌注可引起肺磷脂组份的明显改变。PC和PE在再灌注后出现降低 ,其中PC降低明显 ,于 72h较缺血前降低 35 .1% ;而PI于再灌注后 48h、PS在 2 4h分别增加2 9.0 %和 37.9% ;SM在再灌注后 6h增加达峰值后下降 ,至 72h接近缺血前水平 ;其它磷脂在再灌注后明显升高 ,较缺血前增加 1倍以上。相关分析提示PC的改变与其他组份无明显相关性 ,PE、PS的变化则与SM呈显著负相关。结论 肠道IIR可致肺磷脂组份的明显改变 ,可能是肠道IIR后肺损伤的重要机制之一。
Objective To observe the effect of intestinal ischemia-reperfusion (IIR) injury on pulmonary lecithin. Methods IIR rat model; pulmonary phlebitis components by capillary electrophoresis analysis. Results Intestinal ischemia 60 min reperfusion can cause significant changes in pulmonary phospholipid components. PC and PE decreased after reperfusion, in which PC decreased significantly, which was 35.1% lower than that before ischemia at 72h; PS increased 29.09% and 37.9% respectively at 24h after reperfusion; 6h after reperfusion increased peak value, then dropped to 72h close to the pre-ischemic level; other phospholipids significantly increased after reperfusion, increased more than 1 times before ischemia. Correlation analysis showed that there was no significant correlation between changes of PC and other components, and changes of PE and PS were negatively correlated with SM. Conclusion Intestinal IIR can cause significant changes in pulmonary phospholipid components may be one of the important mechanisms of intestinal injury after IIR.