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目的:探讨冠心病,不稳定心绞痛患者血清心肌肌钙蛋白I(cTnI)持续升高与远期心脏事件的相关性。方法:对71例冠心病,不稳定心绞痛患者根据cTnI的动态变化分为二组,cTnI持续性升高组,cTnI短暂升高组。随访患者远期心脏事件,分析cTnI持续性升高与心脏事件的相关因素。结果:对71例cTnI升高的冠心病,不稳定心绞痛患者进行了远期随访,随访时间31±12月,共有43例患者发生心脏事件57例次。cTnI持续性升高组发生心性死亡8例,cTnI短暂升高组发生心性死亡2例,两组相比有显著性差异,P<0.01。cTnI持续性升高组次要终点事件21例,发生率67.7%。cTnI短暂升高组12例,发生率30%。两组相比有显著性差异,P<0.01。结论:cTnI持续升高的冠心病,其心性死亡及心脏事件发生率显著升高,cTnI是冠心病远期心脏事件的预测因子。
Objective: To investigate the relationship between prolonged cardiac troponin I (cTnI) and long-term cardiac events in patients with coronary heart disease and unstable angina. Methods: Seventy-one patients with coronary heart disease and unstable angina were divided into two groups according to the dynamic changes of cTnI: cTnI sustained increase group and cTnI transient increase group. Follow-up of patients with long-term cardiac events, analysis of cTnI sustained rise and cardiac events related factors. Results: A total of 71 patients with elevated coronary heart disease and unstable angina pectoris were followed up for 31 ± 12 months. A total of 43 patients had 57 heart attacks. There were 8 cases of cardiac death in cTnI persistent increase group and 2 cases of cardiac death in cTnI transient increase group, there was a significant difference between the two groups (P <0.01). In the cTnI sustained increase group, 21 cases were secondary endpoints, the incidence rate was 67.7%. Twelve cases were transiently elevated cTnI, the incidence was 30%. There was significant difference between the two groups, P <0.01. CONCLUSIONS: CtnI is associated with a persistent increase in coronary heart disease with a significant increase in cardiac death and cardiac events. CTnI is a predictor of long-term cardiac events in patients with coronary heart disease.