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目的观察长春瑞滨(vinorelbine,NVB)联合顺铂(cisplatin,DDP)组成的NP方案治疗晚期转移性乳腺癌的临床疗效和不良反应。方法长春瑞滨25 mg/m2加入生理盐水100 ml,快速静脉滴入,d1,8,顺铂60～80 mg/m2分3 d静脉滴注d2-4,21 d为一个周期,每两周期后评价疗效,至少治疗四个周期。结果 38例患者中,完全缓解2例,部分缓解17例,稳定18例,进展1例。总有效率为50.00%,肿瘤控制率(DCR)为92.11%。不良反应主要为恶心、疲乏、呕吐、骨髓抑制、肝肾功能损害、脱发。结论长春瑞宾联合顺铂治疗晚期转移性乳腺癌,疗效较好,不良反应可耐受。
Objective To observe the clinical effects and adverse reactions of vinorelbine (NVB) combined with cisplatin (DDP) in the treatment of advanced metastatic breast cancer. Methods vinorelbine 25 mg / m2 was added to 100 ml of normal saline, rapid intravenous infusion, d1,8, cisplatin 60 ~ 80 mg / m2 3 d intravenous infusion of d2-4,21 d for a cycle, every two cycles After evaluating the efficacy of at least four cycles of treatment. Results 38 patients, complete remission in 2 cases, partial remission in 17 cases, stable in 18 cases, 1 case of progress. The total effective rate was 50.00%, and the tumor control rate (DCR) was 92.11%. Adverse reactions are mainly nausea, fatigue, vomiting, bone marrow suppression, liver and kidney dysfunction, hair loss. Conclusions Vinorelbine combined with cisplatin in the treatment of advanced metastatic breast cancer has better curative effect and tolerable adverse reactions.