口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)是头颈部常见的恶性肿瘤。过去十年里,无论是手术还是放射治疗对OSCC的长期预后和总体生存率均无明显提高~([1]),患者各期平均生存率仅在50%~60%之间~([2])。肿瘤血管生成是影响恶性肿瘤预后的重要因素之一~([3]),其为肿瘤组织生长提供必要的营养物及氧气,并同时清除肿瘤代谢所产生的废物;此外,血管的运输功能亦可使癌细胞远位转 Oral squamous cell carcinoma (OSCC) is a common malignant tumor in the head and neck. In the past decade, no significant improvement was found in the long-term prognosis and overall survival of patients with OSCC, both surgery and radiotherapy. The mean survival rate of patients in each stage was only 50% -60% ]). Tumor angiogenesis is one of the important factors that affect the prognosis of malignant tumors. [3] It provides the necessary nutrients and oxygen for the growth of tumor tissue and simultaneously removes the waste generated by tumor metabolism. In addition, the vascular transport function Can make distant metastasis of cancer cells