目的 :研究动脉内皮细胞在血栓闭塞性脉管炎发病机理中的作用。 方法 :应用扫描电镜技术 ,对血栓闭塞性脉管炎动物模型的动脉内皮细胞进行观察。 结果 :有坏疽症状的动物模型的内皮细胞损伤较重 ,呈无序状排列甚至大片剥脱 ,并有血栓形成。有溃疡症状的动物模型的内皮细胞表现为形态的明显改变和细胞间隙的增大 ,并有血小板的聚集。而红肿症状的动物模型的动脉内皮细胞仅表现为内皮细胞的形态改变。 结论 :动脉内皮的损伤程度与病变的发展程度呈正相关 ,可能是血栓闭塞性脉管炎发病机理的始动环节 Objective: To study the role of arterial endothelial cells in the pathogenesis of thromboangiitis obliterans. Methods: The arterial endothelial cells of thromboangiitis obliterans animal model were observed by scanning electron microscopy. Results: The animal model of gangrene showed severe damage to the endothelial cells, arranged in a disorderly manner and even exfoliated, with thrombosis. Endothelial cells of animal models with ulcer symptoms show marked morphological changes and increased intercellular spaces with platelet aggregation. Arterial endothelial cells of inflamed animal models show only morphological changes of endothelial cells. Conclusion: There is a positive correlation between the degree of injury of arterial endothelium and the development of the disease, which may be the starting point of the pathogenesis of thromboangiitis obliterans