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目的:探讨平原世居人群进入中度海拔(西宁地区,海拔高度2 260m)地区发生急性脑梗死(acute cerebral ischem,ACI)患者血浆同型半胱氨酸、血脂、血糖及血尿酸的变化。方法:对世居中度海拔地区99例ACI患者与73例进入中度海拔地区的世居平原人发生ACI患者,以及64例进入中度海拔地区的世居平原人未发生ACI人群的血浆同型半胱氨酸、血脂、血糖、血尿酸含量行测定、分析。结果:三组血糖(Glu)、血清胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、载脂蛋白A(Apo-A)、载脂蛋白B(Apo-B)含量均无显著性差异(P>0.05),而吸烟史、血浆同型半胱氨酸(Hcy)、高密度脂蛋白(HDL-C)、血尿酸(UA)含量有显著性差异(P<0.001或P<0.01)。结论:Hcy、HDL-C的水平变化、吸烟史与世居平原人群进入中度海拔地区发生急性脑梗死密切相关,而HDL-C水平升高具有保护作用。
Objective: To investigate the changes of plasma homocysteine, serum lipids, blood glucose and serum uric acid in patients with acute cerebral infarction (ACI) who were admitted to moderate altitude (Xining, 2260m above sea level). Methods: A total of 99 ACI patients at moderate altitude and 73 Habitat Plains people at moderate altitude were enrolled as ACI patients, and 64 Homo sapiens Hypochondria Cystine, blood lipids, blood glucose, blood uric acid content determination, analysis. Results: The levels of Glu, TC, TG, LDL-C, Apo-A, Apo-B (P> 0.05), but there was significant difference in smoking history, plasma homocysteine (Hcy), high density lipoprotein (HDL-C) and serum uric acid (UA) 0.001 or P <0.01). CONCLUSION: Hcy, HDL-C level changes and smoking history are closely related to acute cerebral infarction in Habitat plain people entering into moderate altitude area, while HDL-C level has a protective effect.