原发性肝癌亦有肝细胞损伤、坏死、增殖和纤维化,这些改变及肝细胞的恶变与许多细胞因子有关,其中TNF—α与原发性肝癌胶原代谢的关系,报道不一。我们测定了原发性肝细胞性肝癌(HepatocellularCarcinoma,HCC)病人外周血中肿瘤坏死因子α(TNF—α)、人Ⅲ型前胶原(hPcⅢ)、透明质酸(HA)、ALT、γ—GT的水平的变化,并分析了它们之间的相互关系,试图了解HCC患者的细胞因子与肝纤维化的关系。 Primary hepatocellular carcinoma also has liver cell damage, necrosis, proliferation and fibrosis. These changes and hepatocyte malignancy are related to many cytokines. The relationship between TNF-α and collagen metabolism in primary liver cancer is not consistent. We measured tumor necrosis factor-α (TNF-α), human type III procollagen (hPcIII), hyaluronan (HA), ALT, and γ-GT in peripheral blood of patients with primary hepatocellular carcinoma (HCC). The changes in the levels, and analyzed their interrelationships, attempted to understand the relationship between cytokines and liver fibrosis in HCC patients.