认识病因是控制和预防疾病的关键,许多疾病的病因虽不是单一的,却有主次之分。在估计人类肿瘤的病毒病因时,这点极为重要。认为人类的恶性肿瘤常继病毒感染之后发生,支持了病毒致癌的说法。 病毒与动物天然肿瘤 某些肿瘤是可传染的。Ellerman及Rous等分别将鸟白血病及鸟肉瘤的无细胞滤液接种给易感鸟,能使之得病。嗣后,又发现其它一些病毒可使动物致癌(表1)。本文重点讨论疱疹病毒与致瘤病毒。 Recognizing the cause of disease is the key to controlling and preventing diseases. Although the cause of many diseases is not a single one, there are priorities. This is extremely important when estimating the viral cause of human tumors. It is considered that human malignant tumors often occur after the virus infection and support the concept of viral carcinogenesis. Natural tumors of viruses and animals Some tumors are transmissible. Ellerman and Rous et al. inoculated cell-free filtrates of avian leukaemia and avian sarcoma to susceptible birds, which made them ill. Later, they discovered that other viruses can cause cancer in animals (Table 1). This article focuses on herpes viruses and tumorigenic viruses.