介绍了杂多酸 (盐 )型催化剂 Ti Si W1 2 O40 / Ti O2 的制备方法。以自制的Ti Si W1 2 O40 / Ti O2 作为催化剂 ,通过葡萄糖和冰乙酸反应合成了葡萄糖五乙酸酯 ,并探讨了诸因素对产率的影响。实验表明 :Ti Si W1 2 O40 / Ti O2 具有良好的催化活性 ,糖酸摩尔比 1∶ 6 .5 ,催化剂的用量为反应液的 2 .0 % ,酯化反应时间为 2 h,反应温度1 0 2～ 1 0 4℃ ,反应产率可达 89.7%。 The preparation method of heteropoly acid (salt) type catalyst Ti Si W1 2 O40 / Ti O2 is introduced. The self-made Ti Si W1 2 O40 / Ti O2 was used as a catalyst to synthesize glucose pentaacetate by the reaction of glucose and glacial acetic acid. The effects of various factors on the yield were also discussed. The experiments show that: Ti Si W1 2 O40 / Ti O2 has good catalytic activity, sugar-acid molar ratio of 1: 6 .5, the amount of catalyst was 2.0% of the reaction solution, esterification reaction time was 2 h, the reaction temperature 1 0 2 ~ 1 0 4 ℃, the reaction yield up to 89.7%.