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目的 探讨紫癜性肾炎患儿T淋巴细胞改变的特征及其临床意义。方法 采用ELISA法和间接免疫荧光法检测了 5 4例紫癜性肾炎患儿 (APN)血清可溶性白细胞介素 2受体 (sIL - 2R)的水平和外周血T淋巴细胞亚群。结果 急性期患儿sIL - 2R水平明显高于恢复期患儿和正常对照 (P <0 .0 1,P <0 .0 0 1) ,急性期患儿CD8高于正常对照 (P <0 .0 1) ,CD4/CD8比值低于正常对照 (P <0 .0 1)。结论 T细胞功能紊乱是APN病理过程的重要组成部分 ,为通过改善细胞免疫来影响该病的进程提供了理论依据
Objective To investigate the changes of T lymphocytes in children with purpura nephritis and its clinical significance. Methods Serum levels of soluble interleukin 2 receptor (sIL - 2R) and peripheral blood T lymphocyte subsets in 54 children with purpura nephritis (APN) were measured by ELISA and indirect immunofluorescence. Results The level of sIL - 2R in acute stage was significantly higher than that in convalescent stage and normal control group (P <0.01, P <0.01). CD8 in acute stage was higher than that in normal control group (P <0. 0 1), CD4 / CD8 ratio was lower than the normal control (P <0.01). Conclusions T cell dysfunction is an important part of the pathological process of APN and provides a theoretical basis for the process of affecting the disease by improving cellular immunity