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目的通过比较血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF)-α水平,探讨抑郁对不稳定型心绞痛(USP)患者炎性反应的影响。方法连续抽样收集2009年6月15日至2011年3月15日青岛市2家三甲医院住院确诊的USP患者209例,按是否合并抑郁分为USP合并抑郁组72例,单纯USP组137例。所有患者在入选当时和治疗7d后分别测定hs-CRP、TNF-α,对测定结果进行分析对比。结果治疗前后USP合并抑郁组的血清hs-CRP、TNF-α水平均较单纯USP组升高,差异有统计学意义(P均<0.05)。结论 USP合并抑郁有较高的炎性反应水平。
Objective To investigate the effect of depression on the inflammatory response in patients with unstable angina pectoris (USP) by comparing the levels of serum hs-CRP and TNF-α. Methods A total of 209 hospitalized USP patients were collected from two top-three hospitals in Qingdao from June 15, 2009 to March 15, 2011. According to whether they were combined with depression or not, 72 cases were divided into USP combined with depression group and 137 cases with simple USP group. All patients were measured at the time of treatment and after 7d were measured hs-CRP, TNF-α, the results were analyzed and compared. Results The levels of serum hs-CRP and TNF-α in USP combined with depression group before and after treatment were significantly higher than those in simple USP group (all P <0.05). Conclusions USP combined with depression has a higher level of inflammatory response.