作者报告1例庆大霉索引起肾毒性伴方可尼(Fanconi)综合征及尿中酶活性增高。病例:14岁男孩,体重80.9公斤,患G组链球菌所致右眼眶蜂窝织炎,合并全窦炎、脑膜炎与额叶脓肿。由于有青霉素过敏史,故开始用庆大霉素3.7～6.7mg/kg/日及氯霉素。至第22天时测得庆大霉素浓度的低值为3.6μg/ml,峰值达9μg/ml,遂减量。用药第29天药物浓度为低值2μg/ml、峰值16μg/ml,即再减量,于第31天停掉两药。此时患儿血钠为128mEq/L The authors report that one case of Gentamicin induced nephrotoxicity with Fanconi Syndrome and increased urinary enzyme activity. Case: 14-year-old boy, weighing 80.9 kg, suffering from right orbital cellulitis in Group G Streptococcus with total sinusitis, meningitis and frontal abscess. As a history of penicillin allergy, it began with gentamicin 3.7 ~ 6.7mg / kg / day and chloramphenicol. The lowest value of gentamicin measured at day 22 was 3.6 μg / ml with a peak of 9 μg / ml, which was then reduced. On the 29th day of medication, the drug concentration was low 2μg / ml, the peak 16μg / ml, that is, further reduction, the two drugs were stopped on the 31st day. At this time children with serum sodium 128mEq / L