论文部分内容阅读
[目的]探讨活性银离子抗菌液对急性淋巴细胞白血病患儿化疗致口腔溃疡预防效果及其对患儿血浆细胞因子的影响.[方法]选择本院2015年1月至2017年2月期间收治的确诊为急性淋巴细胞白血病的患儿118例,按照随机数表法将其分为观察组和对照组各59例,所有患儿入院后完善各项检查,均采用标准方案进行化疗,化疗期间对照组患儿给予生理盐水或1%双氧水进行常规口腔护理干预,清理完毕后让患儿含漱生理盐水或1%双氧水,观察组患儿在对照组患儿的口腔清理基础上给予活性银离子抗菌液含漱,每次5~10mL,含漱5min,每日于早晚及三餐后各一次,至患儿口腔溃疡恢复.观察记录两组患儿的口腔溃疡发生率及口腔溃疡恢复时间,根据抗癌药物急性及亚急性毒性反应分度标准对患儿的口腔溃疡严重程度进行评定,同时分别在治疗前和治疗后一周,采用酶联免疫吸附测定法(ELISA)对患儿血浆中的白介素-2(IL-2)、干扰素-g(IFN-g)、肿瘤坏死因子-ɑ(TNF-ɑ)等细胞因子水平进行测定.[结果]观察组患儿的口腔溃疡发生率及口腔溃疡恢复时间均显著低于对照组患儿,差异具有统计学意义(P<0.05);观察组患儿的口腔溃疡严重程度显著轻于对照组患儿,两组患儿口腔溃疡严重程度比较差异具有统计学意义(Z=25.162,P<0.05);治疗后两组患儿的TNF-ɑ水平均显著降低,IL-2及IFN-g水平显著升高,且观察组患儿的TNF-ɑ水平明显低于对照组,IL-2及IFN-g水平明显高于对照组,差异均具有统计学意义(P<0.05).[结论]活性银离子抗菌液能够有效预防急性淋巴细胞白血病患儿化疗引起的口腔溃疡,促进口腔溃疡预后,改善患儿血浆IL-2、IFN-g、TNF-ɑ水平,增强患儿免疫功能,值得临床推广应用.“,”[Objective]To investigate the effect of active silver ion antibacterial liquid on the prevention of oral ulcer and the cytokine in plasma of children with acute lymphoblastic leukemia.[Methods]A total of 118 cases of acute lymphoblastic leukemia diagnosed in our hospital from January 2015 to February 2017 were se-lected;according to the random number method,all the patients were randomly divided into the observation/study group(59 cases)and the control group(59 cases);all of the children completed the examination after admission and were treated with standard regimen for chemotherapy,routine oral nursing intervention during chemotherapy;the control group was given 0.9% saline or 1% hydrogen peroxide;on the basis of in the con-trol group,the study group was treated with cleaning up by the active silver ion antibacterial mouthwash oral 5~10 ml,every time,gargle 5 min daily in the morning and evening and after meals each time,to those with oral ulcer recovery.The incidence of oral ulcers and the recovery time of oral ulcers were recorded and recorded in the two groups;the severity of oral ulcer was evaluated according to the standard of acute and subacute tox-icity of anticancer drugs;at the same time before treatment and one week after treatment respectively,plasma interleukin-2(IL-2)and interferon-g(IFN-g),tumor necrosis factor alpha(TNF-alpha)and other cytokines were determined by enzyme-linked immunosorbent assay(ELISA).[Results]The incidence rate of oral ulcer and oral ulcer recovery time of the study group with were significantly lower than the control group,the differ-ence was statistically significant(P <0.05);oral ulcer severity of the study group was significantly lower than that of the control group,the two groups have statistical significance in children with oral ulcer severity difference(Z=25.162,P <0.05);after treatment,TNF-ɑ of the two groups of children was significantly de-creased,IL-2 and IFN-g were significantly increased;after treatment,the level of TNF-ɑ of the study group was significantly lower than that of the control group,while the IL-2 and IFN-g levels were significantly higher than those the control group,the differences were statistically significant(P <0.05).[Conclusion]Active sil-ver ion antibacterial liquid can effectively prevent children from acute lymphoblastic leukemia oral ulcers in-duced by chemotherapy,and promote the prognosis,improve plasma IL-2,IFN-g and TNF-ɑ levels,and en-hance the immune function of children.It is worthy of clinical application.